Review the Research<\/p>\n
Get summaries of key research on vitamin D and COVID-19<\/h5><\/div><\/div><\/div><\/div><\/div>\nEffects of Vitamin D Serum Level on Morbidity<\/span> and Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis<\/span><\/h1><\/div>Take Home Message<\/span><\/h2><\/div>his analysis reported no statistical difference in mortality, ICU admission rate, ventilator support, or length of hospital stay in COVID-19 patients with low and high vitamin D serum concentration.<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Results<\/span><\/h2><\/div><\/div><\/div>\n- Vitamin D<\/span> serum\u00a0concentration<\/span> was not<\/span> statistically associated with mortality and ICU admission, ventilator support requirement, and length of hospital stay.<\/span><\/span>\u00a0<\/span><\/li>\n<\/ul>\n
\u00a0<\/span><\/p>\n<\/div><\/div><\/div>![](\"https:\/\/www.vitamindandme.org\/wp-content\/uploads\/2023\/05\/127-HU-300x200.jpg\" "\\"Stressed")
<\/span><\/div><\/div><\/div><\/div><\/div>Who<\/span><\/h2><\/div>20 studies <\/span>including <\/span>12,<\/span>806 patients aged between 42 to 81 years old were analyzed.<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Things to Keep in Mind<\/span><\/h2><\/div>\n- This analysis included just 20 observational studies which were retrospective, no intervention was performed.<\/span>\u00a0<\/span><\/li>\n
- Many studies did not report or control for confounding and comorbidities.<\/li>\n
- Studies varied in timing serum vitamin D measurement relative to disease onset.<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div>
Author\u2019s Conclusions<\/span><\/h2><\/div><\/div><\/div>“<\/span><\/h2><\/div><\/div><\/div>There is no statistical difference in mortality {RR 1.02 (95% CI: 0.74, 1.42)},<\/span> ICU<\/span> admission rate {RR 0.87 (95% CI: 0.67, 1.14)}, <\/span>ventilator support requirement {RR was 1.29 (95% CI: 0.79, 1.84)}, and length of hospital stay {0.84 (95% CI -0.45, 2.13)}<\/span> in <\/span>COVID-19 patients\u00a0with low\u00a0and\u00a0high Vitamin\u00a0D\u00a0serum<\/span> concentration. <\/span>Additional<\/span> randomized controlled trials<\/span> are needed to <\/span>provide<\/span> a <\/span>specific\u00a0<\/span>supplemental<\/span>\u00a0vitamin<\/span> dose<\/span> and Vitamin<\/span> D serum concentration to target.<\/span><\/p>\n<\/div><\/div><\/div>“<\/span><\/h2><\/div><\/div><\/div><\/div><\/div>Study Design<\/span><\/h2><\/div>\n- This systematic review and meta-analysis was conducted to determine the effects of Vitamin D serum concentration on mortality and morbidity in COVID-19 patients.<\/span><\/li>\n
- The primary objectives were to determine if Vitamin D serum concentration decrease mortality, ICU admissions, ventilator support, and length of hospital stay in COVID-19 patients.<\/span>\u00a0<\/span><\/li>\n
- Ovid MEDLINE, Ovid Embase, CINAHL, Scopus, Web of Science Core Collection, and Cochrane Library (via Wiley), clinicaltrials.gov, google scholar first 200 and study bibliographies were searched on May 1, 2021.<\/span><\/li>\n
- The\u00a0meta-analysis consisted of randomized controlled, and observational studies with the following inclusion criteria: 1) COVID-19 positive patients, 2) low Vitamin D serum concentration group, 3) normal Vitamin D serum concentration group, 4) mortality, 5) intensive care unit (ICU) admission, 6) ventilator support, and 7) length of hospital stay.<\/span>\u00a0<\/span><\/li>\n<\/ul>\n
\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Reference<\/span><\/h2><\/div>Hu Y, Kung J, Cave A, Banh HL. Effects of Vitamin D Serum Level on Morbidity and Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis. J Pharm <\/span>Pharm<\/span> Sci. <\/span>2022;25:84<\/span>-92. <\/span>doi<\/span>: 10.18433\/jpps32590. PMID: 35245430.<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div>
Effects of Vitamin D Serum Level on Morbidity<\/span> and Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis<\/span><\/h1><\/div>Take Home Message<\/span><\/h2><\/div>his analysis reported no statistical difference in mortality, ICU admission rate, ventilator support, or length of hospital stay in COVID-19 patients with low and high vitamin D serum concentration.<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Results<\/span><\/h2><\/div><\/div><\/div>\n- Vitamin D<\/span> serum\u00a0concentration<\/span> was not<\/span> statistically associated with mortality and ICU admission, ventilator support requirement, and length of hospital stay.<\/span><\/span>\u00a0<\/span><\/li>\n<\/ul>\n
\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/span><\/div><\/div><\/div><\/div><\/div>Who<\/span><\/h2><\/div>20 studies <\/span>including <\/span>12,<\/span>806 patients aged between 42 to 81 years old were analyzed.<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Things to Keep in Mind<\/span><\/h2><\/div>\n- This analysis included just 20 observational studies which were retrospective, no intervention was performed.<\/span>\u00a0<\/span><\/li>\n
- Many studies did not report or control for confounding and comorbidities.<\/li>\n
- Studies varied in timing serum vitamin D measurement relative to disease onset.<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div>
Author\u2019s Conclusions<\/span><\/h2><\/div><\/div><\/div>“<\/span><\/h2><\/div><\/div><\/div>There is no statistical difference in mortality {RR 1.02 (95% CI: 0.74, 1.42)},<\/span> ICU<\/span> admission rate {RR 0.87 (95% CI: 0.67, 1.14)}, <\/span>ventilator support requirement {RR was 1.29 (95% CI: 0.79, 1.84)}, and length of hospital stay {0.84 (95% CI -0.45, 2.13)}<\/span> in <\/span>COVID-19 patients\u00a0with low\u00a0and\u00a0high Vitamin\u00a0D\u00a0serum<\/span> concentration. <\/span>Additional<\/span> randomized controlled trials<\/span> are needed to <\/span>provide<\/span> a <\/span>specific\u00a0<\/span>supplemental<\/span>\u00a0vitamin<\/span> dose<\/span> and Vitamin<\/span> D serum concentration to target.<\/span><\/p>\n<\/div><\/div><\/div>“<\/span><\/h2><\/div><\/div><\/div><\/div><\/div>Study Design<\/span><\/h2><\/div>\n- This systematic review and meta-analysis was conducted to determine the effects of Vitamin D serum concentration on mortality and morbidity in COVID-19 patients.<\/span><\/li>\n
- The primary objectives were to determine if Vitamin D serum concentration decrease mortality, ICU admissions, ventilator support, and length of hospital stay in COVID-19 patients.<\/span>\u00a0<\/span><\/li>\n
- Ovid MEDLINE, Ovid Embase, CINAHL, Scopus, Web of Science Core Collection, and Cochrane Library (via Wiley), clinicaltrials.gov, google scholar first 200 and study bibliographies were searched on May 1, 2021.<\/span><\/li>\n
- The\u00a0meta-analysis consisted of randomized controlled, and observational studies with the following inclusion criteria: 1) COVID-19 positive patients, 2) low Vitamin D serum concentration group, 3) normal Vitamin D serum concentration group, 4) mortality, 5) intensive care unit (ICU) admission, 6) ventilator support, and 7) length of hospital stay.<\/span>\u00a0<\/span><\/li>\n<\/ul>\n
\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Reference<\/span><\/h2><\/div>Hu Y, Kung J, Cave A, Banh HL. Effects of Vitamin D Serum Level on Morbidity and Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis. J Pharm <\/span>Pharm<\/span> Sci. <\/span>2022;25:84<\/span>-92. <\/span>doi<\/span>: 10.18433\/jpps32590. PMID: 35245430.<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div>
Take Home Message<\/span><\/h2><\/div>his analysis reported no statistical difference in mortality, ICU admission rate, ventilator support, or length of hospital stay in COVID-19 patients with low and high vitamin D serum concentration.<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Results<\/span><\/h2><\/div><\/div><\/div>\n- Vitamin D<\/span> serum\u00a0concentration<\/span> was not<\/span> statistically associated with mortality and ICU admission, ventilator support requirement, and length of hospital stay.<\/span><\/span>\u00a0<\/span><\/li>\n<\/ul>\n
\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/span><\/div><\/div><\/div><\/div><\/div>Who<\/span><\/h2><\/div>20 studies <\/span>including <\/span>12,<\/span>806 patients aged between 42 to 81 years old were analyzed.<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Things to Keep in Mind<\/span><\/h2><\/div>\n- This analysis included just 20 observational studies which were retrospective, no intervention was performed.<\/span>\u00a0<\/span><\/li>\n
- Many studies did not report or control for confounding and comorbidities.<\/li>\n
- Studies varied in timing serum vitamin D measurement relative to disease onset.<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div>
Author\u2019s Conclusions<\/span><\/h2><\/div><\/div><\/div>“<\/span><\/h2><\/div><\/div><\/div>There is no statistical difference in mortality {RR 1.02 (95% CI: 0.74, 1.42)},<\/span> ICU<\/span> admission rate {RR 0.87 (95% CI: 0.67, 1.14)}, <\/span>ventilator support requirement {RR was 1.29 (95% CI: 0.79, 1.84)}, and length of hospital stay {0.84 (95% CI -0.45, 2.13)}<\/span> in <\/span>COVID-19 patients\u00a0with low\u00a0and\u00a0high Vitamin\u00a0D\u00a0serum<\/span> concentration. <\/span>Additional<\/span> randomized controlled trials<\/span> are needed to <\/span>provide<\/span> a <\/span>specific\u00a0<\/span>supplemental<\/span>\u00a0vitamin<\/span> dose<\/span> and Vitamin<\/span> D serum concentration to target.<\/span><\/p>\n<\/div><\/div><\/div>“<\/span><\/h2><\/div><\/div><\/div><\/div><\/div>Study Design<\/span><\/h2><\/div>\n- This systematic review and meta-analysis was conducted to determine the effects of Vitamin D serum concentration on mortality and morbidity in COVID-19 patients.<\/span><\/li>\n
- The primary objectives were to determine if Vitamin D serum concentration decrease mortality, ICU admissions, ventilator support, and length of hospital stay in COVID-19 patients.<\/span>\u00a0<\/span><\/li>\n
- Ovid MEDLINE, Ovid Embase, CINAHL, Scopus, Web of Science Core Collection, and Cochrane Library (via Wiley), clinicaltrials.gov, google scholar first 200 and study bibliographies were searched on May 1, 2021.<\/span><\/li>\n
- The\u00a0meta-analysis consisted of randomized controlled, and observational studies with the following inclusion criteria: 1) COVID-19 positive patients, 2) low Vitamin D serum concentration group, 3) normal Vitamin D serum concentration group, 4) mortality, 5) intensive care unit (ICU) admission, 6) ventilator support, and 7) length of hospital stay.<\/span>\u00a0<\/span><\/li>\n<\/ul>\n
\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Reference<\/span><\/h2><\/div>Hu Y, Kung J, Cave A, Banh HL. Effects of Vitamin D Serum Level on Morbidity and Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis. J Pharm <\/span>Pharm<\/span> Sci. <\/span>2022;25:84<\/span>-92. <\/span>doi<\/span>: 10.18433\/jpps32590. PMID: 35245430.<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div>
his analysis reported no statistical difference in mortality, ICU admission rate, ventilator support, or length of hospital stay in COVID-19 patients with low and high vitamin D serum concentration.<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div> \u00a0<\/span><\/p>\n<\/div><\/div><\/div> 20 studies <\/span>including <\/span>12,<\/span>806 patients aged between 42 to 81 years old were analyzed.<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div> There is no statistical difference in mortality {RR 1.02 (95% CI: 0.74, 1.42)},<\/span> ICU<\/span> admission rate {RR 0.87 (95% CI: 0.67, 1.14)}, <\/span>ventilator support requirement {RR was 1.29 (95% CI: 0.79, 1.84)}, and length of hospital stay {0.84 (95% CI -0.45, 2.13)}<\/span> in <\/span>COVID-19 patients\u00a0with low\u00a0and\u00a0high Vitamin\u00a0D\u00a0serum<\/span> concentration. <\/span>Additional<\/span> randomized controlled trials<\/span> are needed to <\/span>provide<\/span> a <\/span>specific\u00a0<\/span>supplemental<\/span>\u00a0vitamin<\/span> dose<\/span> and Vitamin<\/span> D serum concentration to target.<\/span><\/p>\n<\/div><\/div><\/div> \u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div> Hu Y, Kung J, Cave A, Banh HL. Effects of Vitamin D Serum Level on Morbidity and Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis. J Pharm <\/span>Pharm<\/span> Sci. <\/span>2022;25:84<\/span>-92. <\/span>doi<\/span>: 10.18433\/jpps32590. PMID: 35245430.<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div>Results<\/span><\/h2><\/div><\/div><\/div>
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<\/span><\/div><\/div><\/div><\/div><\/div>Who<\/span><\/h2><\/div>
Things to Keep in Mind<\/span><\/h2><\/div>
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Author\u2019s Conclusions<\/span><\/h2><\/div><\/div><\/div>
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Study Design<\/span><\/h2><\/div>
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Reference<\/span><\/h2><\/div>