Review the Research<\/p>\n
Get summaries of key research on vitamin D and COVID-19<\/h5><\/div><\/div><\/div><\/div><\/div>\nVitamin D and morbidity in children with multisystem inflammatory syndrome related to Covid-19.<\/span><\/span><\/h1><\/div>Take Home Message<\/span><\/h2><\/div>This study showed a<\/span> <\/span>potential association between severe vitamin D deficiency and severe covid-19 in children with multisystem inflammatory<\/span> syndrome<\/span>.<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Results<\/span><\/h2><\/div><\/div><\/div>\n- Ten patients had severe vitamin D deficiency with a mean level of 7.2 ng\/ml.\u00a0<\/span>\u00a0<\/span><\/li>\n
- Ninety percent of patients with severe vitamin D deficiency had severe disease (P < 0.001). Patients with severe vitamin D deficiency had an increased risk of cardiac involvement (P < 0.001).<\/span>\u00a0<\/span><\/li>\n
- There were 13 (41.9%) patients who had cardiac involvement. It consisted of 12 patients with ventricular dysfunction, 4 patients with coronary artery involvement, 5 patients had pericardial effusion and 9 patients had an abnormal electrocardiogram.\u00a0<\/span>\u00a0<\/span><\/li>\n
- The group with cardiac involvement had a mean (SD) 25-OH vitamin D level of 9.6 (4.3) ng\/ml vs. 23.7 (10.6) ng\/ml for the rest of the cohort (P < 0.01).\u00a0<\/span>\u00a0<\/span><\/li>\n
- The group with severe vitamin D deficiency had an increased risk of cardiac involvement (OR: 38.3; 95% CI; 3.7\u2013395.3; P < 0.01).\u00a0<\/span>\u00a0<\/span><\/li>\n
- Those with severe vitamin D deficiency had reduced left ventricular ejection and shortening fraction compared to the group with non-severe vitamin D deficiency (P < 0.001).<\/span>\u00a0<\/span><\/li>\n<\/ul>\n<\/div><\/div><\/div>
![](\"https:\/\/www.vitamindandme.org\/wp-content\/uploads\/2022\/09\/116-Torpoco-Rivera-300x200.jpg\" "\\"Mother")
<\/span><\/div><\/div><\/div><\/div><\/div>Who<\/span><\/h2><\/div>31 <\/span>h<\/span>ospitalized patients <\/span>aged between 1 and 13 years, 45% male<\/span><\/span>,<\/span><\/span><\/span> 58% African American,<\/span> with diagnosis of Multisystem inflammatory syndrome (MIS-C<\/span>).<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Things to Keep in Mind<\/span><\/h2><\/div>\n- The study is a single center retrospective study with a relatively small number of patients.<\/span><\/li>\n
- Data collection and statistical analysis were limited to data already recorded in the medical records.<\/span><\/li>\n
- There was no control for confounding.<\/span>\u00a0<\/span><\/li>\n
- This study only assessed a small number of children under the age of 13, limiting the generalizability.<\/span>\u00a0<\/span><\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div>
Author\u2019s Conclusions<\/span><\/h2><\/div><\/div><\/div>\u201c<\/span>We describe a potential association between severe vitamin D deficiency and severe disease in children presenting with MIS-C due to Covid-19. Severe vitamin D deficiency predisposes patients for cardiovascular involvement due to altered cellular homeostasis mediated by widespread VDRs in the cardiovascular system. Furthermore, the immune modulatory activity of vitamin D may play a critical role in the host immune response to Covid-19 infection. Future prospective studies at the basic science and clinical level should be pursued to better delineate this association<\/span>.\u201d<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Study Design<\/span><\/h2><\/div>\n- This is a retrospective and single center study.<\/span>\u00a0<\/span><\/li>\n
- The study included hospitalized patients less than 18 years of age with diagnosis of Multisystem inflammatory syndrome (MIS-C) between March and July 2020. Severe vitamin D deficiency was defined as 25-OH vitamin D level < 10 ng\/ml within 48 h of admission. The composite outcome severe disease included patients requiring inotropes, mechanical ventilation, and extracorporeal membrane oxygenation.<\/span><\/li>\n<\/ul>\n
\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Reference<\/span><\/h2><\/div>Torpoco<\/span>-Rivera D, <\/span>Misra<\/span> A, <\/span>Sanil<\/span> Y, <\/span>Sabzghabaei<\/span> N, Safa R, Garcia RU. Vitamin D and morbidity in children with multisystem inflammatory syndrome related to Covid-19. Prog <\/span>Pediatr<\/span> Cardiol<\/span>. 2022 Mar 1:101507. <\/span>doi<\/span>: 10.1016\/j.ppedcard.2022.101507. <\/span>Epub<\/span> ahead of print. PMID: 35250251; PMCID: PMC8885084.<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div>
Vitamin D and morbidity in children with multisystem inflammatory syndrome related to Covid-19.<\/span><\/span><\/h1><\/div>Take Home Message<\/span><\/h2><\/div>This study showed a<\/span> <\/span>potential association between severe vitamin D deficiency and severe covid-19 in children with multisystem inflammatory<\/span> syndrome<\/span>.<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Results<\/span><\/h2><\/div><\/div><\/div>\n- Ten patients had severe vitamin D deficiency with a mean level of 7.2 ng\/ml.\u00a0<\/span>\u00a0<\/span><\/li>\n
- Ninety percent of patients with severe vitamin D deficiency had severe disease (P < 0.001). Patients with severe vitamin D deficiency had an increased risk of cardiac involvement (P < 0.001).<\/span>\u00a0<\/span><\/li>\n
- There were 13 (41.9%) patients who had cardiac involvement. It consisted of 12 patients with ventricular dysfunction, 4 patients with coronary artery involvement, 5 patients had pericardial effusion and 9 patients had an abnormal electrocardiogram.\u00a0<\/span>\u00a0<\/span><\/li>\n
- The group with cardiac involvement had a mean (SD) 25-OH vitamin D level of 9.6 (4.3) ng\/ml vs. 23.7 (10.6) ng\/ml for the rest of the cohort (P < 0.01).\u00a0<\/span>\u00a0<\/span><\/li>\n
- The group with severe vitamin D deficiency had an increased risk of cardiac involvement (OR: 38.3; 95% CI; 3.7\u2013395.3; P < 0.01).\u00a0<\/span>\u00a0<\/span><\/li>\n
- Those with severe vitamin D deficiency had reduced left ventricular ejection and shortening fraction compared to the group with non-severe vitamin D deficiency (P < 0.001).<\/span>\u00a0<\/span><\/li>\n<\/ul>\n<\/div><\/div><\/div><\/span><\/div><\/div><\/div><\/div><\/div>
Who<\/span><\/h2><\/div>31 <\/span>h<\/span>ospitalized patients <\/span>aged between 1 and 13 years, 45% male<\/span><\/span>,<\/span><\/span><\/span> 58% African American,<\/span> with diagnosis of Multisystem inflammatory syndrome (MIS-C<\/span>).<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Things to Keep in Mind<\/span><\/h2><\/div>\n- The study is a single center retrospective study with a relatively small number of patients.<\/span><\/li>\n
- Data collection and statistical analysis were limited to data already recorded in the medical records.<\/span><\/li>\n
- There was no control for confounding.<\/span>\u00a0<\/span><\/li>\n
- This study only assessed a small number of children under the age of 13, limiting the generalizability.<\/span>\u00a0<\/span><\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div>
Author\u2019s Conclusions<\/span><\/h2><\/div><\/div><\/div>\u201c<\/span>We describe a potential association between severe vitamin D deficiency and severe disease in children presenting with MIS-C due to Covid-19. Severe vitamin D deficiency predisposes patients for cardiovascular involvement due to altered cellular homeostasis mediated by widespread VDRs in the cardiovascular system. Furthermore, the immune modulatory activity of vitamin D may play a critical role in the host immune response to Covid-19 infection. Future prospective studies at the basic science and clinical level should be pursued to better delineate this association<\/span>.\u201d<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Study Design<\/span><\/h2><\/div>\n- This is a retrospective and single center study.<\/span>\u00a0<\/span><\/li>\n
- The study included hospitalized patients less than 18 years of age with diagnosis of Multisystem inflammatory syndrome (MIS-C) between March and July 2020. Severe vitamin D deficiency was defined as 25-OH vitamin D level < 10 ng\/ml within 48 h of admission. The composite outcome severe disease included patients requiring inotropes, mechanical ventilation, and extracorporeal membrane oxygenation.<\/span><\/li>\n<\/ul>\n
\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Reference<\/span><\/h2><\/div>Torpoco<\/span>-Rivera D, <\/span>Misra<\/span> A, <\/span>Sanil<\/span> Y, <\/span>Sabzghabaei<\/span> N, Safa R, Garcia RU. Vitamin D and morbidity in children with multisystem inflammatory syndrome related to Covid-19. Prog <\/span>Pediatr<\/span> Cardiol<\/span>. 2022 Mar 1:101507. <\/span>doi<\/span>: 10.1016\/j.ppedcard.2022.101507. <\/span>Epub<\/span> ahead of print. PMID: 35250251; PMCID: PMC8885084.<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div>
Take Home Message<\/span><\/h2><\/div>This study showed a<\/span> <\/span>potential association between severe vitamin D deficiency and severe covid-19 in children with multisystem inflammatory<\/span> syndrome<\/span>.<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Results<\/span><\/h2><\/div><\/div><\/div>\n- Ten patients had severe vitamin D deficiency with a mean level of 7.2 ng\/ml.\u00a0<\/span>\u00a0<\/span><\/li>\n
- Ninety percent of patients with severe vitamin D deficiency had severe disease (P < 0.001). Patients with severe vitamin D deficiency had an increased risk of cardiac involvement (P < 0.001).<\/span>\u00a0<\/span><\/li>\n
- There were 13 (41.9%) patients who had cardiac involvement. It consisted of 12 patients with ventricular dysfunction, 4 patients with coronary artery involvement, 5 patients had pericardial effusion and 9 patients had an abnormal electrocardiogram.\u00a0<\/span>\u00a0<\/span><\/li>\n
- The group with cardiac involvement had a mean (SD) 25-OH vitamin D level of 9.6 (4.3) ng\/ml vs. 23.7 (10.6) ng\/ml for the rest of the cohort (P < 0.01).\u00a0<\/span>\u00a0<\/span><\/li>\n
- The group with severe vitamin D deficiency had an increased risk of cardiac involvement (OR: 38.3; 95% CI; 3.7\u2013395.3; P < 0.01).\u00a0<\/span>\u00a0<\/span><\/li>\n
- Those with severe vitamin D deficiency had reduced left ventricular ejection and shortening fraction compared to the group with non-severe vitamin D deficiency (P < 0.001).<\/span>\u00a0<\/span><\/li>\n<\/ul>\n<\/div><\/div><\/div><\/span><\/div><\/div><\/div><\/div><\/div>
Who<\/span><\/h2><\/div>31 <\/span>h<\/span>ospitalized patients <\/span>aged between 1 and 13 years, 45% male<\/span><\/span>,<\/span><\/span><\/span> 58% African American,<\/span> with diagnosis of Multisystem inflammatory syndrome (MIS-C<\/span>).<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Things to Keep in Mind<\/span><\/h2><\/div>\n- The study is a single center retrospective study with a relatively small number of patients.<\/span><\/li>\n
- Data collection and statistical analysis were limited to data already recorded in the medical records.<\/span><\/li>\n
- There was no control for confounding.<\/span>\u00a0<\/span><\/li>\n
- This study only assessed a small number of children under the age of 13, limiting the generalizability.<\/span>\u00a0<\/span><\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div>
Author\u2019s Conclusions<\/span><\/h2><\/div><\/div><\/div>\u201c<\/span>We describe a potential association between severe vitamin D deficiency and severe disease in children presenting with MIS-C due to Covid-19. Severe vitamin D deficiency predisposes patients for cardiovascular involvement due to altered cellular homeostasis mediated by widespread VDRs in the cardiovascular system. Furthermore, the immune modulatory activity of vitamin D may play a critical role in the host immune response to Covid-19 infection. Future prospective studies at the basic science and clinical level should be pursued to better delineate this association<\/span>.\u201d<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Study Design<\/span><\/h2><\/div>\n- This is a retrospective and single center study.<\/span>\u00a0<\/span><\/li>\n
- The study included hospitalized patients less than 18 years of age with diagnosis of Multisystem inflammatory syndrome (MIS-C) between March and July 2020. Severe vitamin D deficiency was defined as 25-OH vitamin D level < 10 ng\/ml within 48 h of admission. The composite outcome severe disease included patients requiring inotropes, mechanical ventilation, and extracorporeal membrane oxygenation.<\/span><\/li>\n<\/ul>\n
\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Reference<\/span><\/h2><\/div>Torpoco<\/span>-Rivera D, <\/span>Misra<\/span> A, <\/span>Sanil<\/span> Y, <\/span>Sabzghabaei<\/span> N, Safa R, Garcia RU. Vitamin D and morbidity in children with multisystem inflammatory syndrome related to Covid-19. Prog <\/span>Pediatr<\/span> Cardiol<\/span>. 2022 Mar 1:101507. <\/span>doi<\/span>: 10.1016\/j.ppedcard.2022.101507. <\/span>Epub<\/span> ahead of print. PMID: 35250251; PMCID: PMC8885084.<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div>
This study showed a<\/span> <\/span>potential association between severe vitamin D deficiency and severe covid-19 in children with multisystem inflammatory<\/span> syndrome<\/span>.<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div> 31 <\/span>h<\/span>ospitalized patients <\/span>aged between 1 and 13 years, 45% male<\/span><\/span>,<\/span><\/span><\/span> 58% African American,<\/span> with diagnosis of Multisystem inflammatory syndrome (MIS-C<\/span>).<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div> \u201c<\/span>We describe a potential association between severe vitamin D deficiency and severe disease in children presenting with MIS-C due to Covid-19. Severe vitamin D deficiency predisposes patients for cardiovascular involvement due to altered cellular homeostasis mediated by widespread VDRs in the cardiovascular system. Furthermore, the immune modulatory activity of vitamin D may play a critical role in the host immune response to Covid-19 infection. Future prospective studies at the basic science and clinical level should be pursued to better delineate this association<\/span>.\u201d<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div> \u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div> Torpoco<\/span>-Rivera D, <\/span>Misra<\/span> A, <\/span>Sanil<\/span> Y, <\/span>Sabzghabaei<\/span> N, Safa R, Garcia RU. Vitamin D and morbidity in children with multisystem inflammatory syndrome related to Covid-19. Prog <\/span>Pediatr<\/span> Cardiol<\/span>. 2022 Mar 1:101507. <\/span>doi<\/span>: 10.1016\/j.ppedcard.2022.101507. <\/span>Epub<\/span> ahead of print. PMID: 35250251; PMCID: PMC8885084.<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div>Results<\/span><\/h2><\/div><\/div><\/div>
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<\/span><\/div><\/div><\/div><\/div><\/div>Who<\/span><\/h2><\/div>
Things to Keep in Mind<\/span><\/h2><\/div>
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Author\u2019s Conclusions<\/span><\/h2><\/div><\/div><\/div>
Study Design<\/span><\/h2><\/div>
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Reference<\/span><\/h2><\/div>