Review the Research<\/p>\n
Get summaries of key research on vitamin D and COVID-19<\/h5><\/div><\/div><\/div><\/div><\/div>\nAssociation of Vitamin D Status and COVID-19-Related Hospitalization and Mortality<\/span><\/span><\/h1><\/div>Take Home Message<\/span><\/h2><\/div>Vitamin D deficiency has a significant dose-response relationship with adverse clinical <\/span>outcomes<\/span> of COVID-19 infection, including hospitalization and mortali<\/span>ty.<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Results<\/span><\/h2><\/div><\/div><\/div>\n- \n
\n- 14.5% had vitamin D deficiency (< 20 ng\/dl).<\/span>\u00a0<\/span><\/li>\n<\/ul>\n
\n- African American patients, patients living in areas of high poverty, and those with alcohol and drug use had the highest risk for low vitamin D levels.<\/span>\u00a0<\/span><\/li>\n
- There is a significant inverse relationship between vitamin D concentrations and COVID-19 related hospitalization.<\/span>\u00a0<\/span><\/li>\n
- Patients with lower vitamin D concentrations, increases in vitamin D are associated with larger reductions in probability for hospitalization than among those with higher vitamin D concentrations.<\/span>\u00a0<\/span><\/li>\n
- COVID patients with a vitamin D level of 15 ng\/ml compared to 40 ng\/ml had a 20% greater with of hospitalization.\u00a0<\/span>\u00a0<\/span><\/li>\n
- COVID patients with a vitamin D level of 15 ng\/ml compared to 40 ng\/ml had a 53% increased risk of mortality.\u00a0<\/span>\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div><\/div><\/div>
![](\"https:\/\/www.vitamindandme.org\/wp-content\/uploads\/2022\/08\/Seal97-300x200.jpg\" "\\"Dad")
<\/span><\/div><\/div><\/div><\/div><\/div>Who<\/span><\/h2><\/div>Veterans enrolled in the VA health care systems across the US<\/span> that tested for COVID-19 (71,175<\/span> patients<\/span>).<\/span> 4,599 patients had vitamin D levels tested within 15-90 days of their COVID-19 tests.<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Things to Keep in Mind<\/span><\/h2><\/div>This is a straightforward chart review and comparison, but it should be noted that these patients were all hospitalized which one can assume means these were the worst cases, and we don\u2019t know about health conditions not reviewed in the study that might increase risk and severity of symptoms or might influence vitamin D status.<\/span><\/p>\n <\/p>\n<\/div><\/div><\/div><\/div><\/div>
Author\u2019s Conclusions<\/span><\/h2><\/div><\/div><\/div>“<\/span><\/h2><\/div><\/div><\/div>Continuous blood 25(OH)D concentrations are independently associated with COVID-19-related hospitalization and mortality in an inverse dose-response relationship in this large racially and ethnically diverse cohort of VA patients. Randomized controlled trials are needed to evaluate the impact of vitamin D supplementation on COVID-19-related outcomes.<\/span><\/span><\/p>\n<\/div><\/div><\/div>“<\/span><\/h2><\/div><\/div><\/div><\/div><\/div>Study Design<\/span><\/h2><\/div>\n- Retrospective Cohort Study<\/span><\/span><\/li>\n<\/ul>\n
\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Reference<\/span><\/h2><\/div>Seal KH, <\/span>Bertenthal<\/span> D, Carey E, Grunfeld C, <\/span>Bikle<\/span> DD, Lu CM. Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality. J Gen Intern Med. 2022 Jan 1:1\u20139. <\/span>doi<\/span>: 10.1007\/s11606-021-07170-0. <\/span>Epub<\/span> ahead of print. PMID: 34981368; PMCID: PMC8723909.<\/span><\/p>\n<\/div><\/div><\/div>
Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality<\/span><\/span><\/h1><\/div>Take Home Message<\/span><\/h2><\/div>Vitamin D deficiency has a significant dose-response relationship with adverse clinical <\/span>outcomes<\/span> of COVID-19 infection, including hospitalization and mortali<\/span>ty.<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Results<\/span><\/h2><\/div><\/div><\/div>\n- \n
\n- 14.5% had vitamin D deficiency (< 20 ng\/dl).<\/span>\u00a0<\/span><\/li>\n<\/ul>\n
\n- African American patients, patients living in areas of high poverty, and those with alcohol and drug use had the highest risk for low vitamin D levels.<\/span>\u00a0<\/span><\/li>\n
- There is a significant inverse relationship between vitamin D concentrations and COVID-19 related hospitalization.<\/span>\u00a0<\/span><\/li>\n
- Patients with lower vitamin D concentrations, increases in vitamin D are associated with larger reductions in probability for hospitalization than among those with higher vitamin D concentrations.<\/span>\u00a0<\/span><\/li>\n
- COVID patients with a vitamin D level of 15 ng\/ml compared to 40 ng\/ml had a 20% greater with of hospitalization.\u00a0<\/span>\u00a0<\/span><\/li>\n
- COVID patients with a vitamin D level of 15 ng\/ml compared to 40 ng\/ml had a 53% increased risk of mortality.\u00a0<\/span>\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/span><\/div><\/div><\/div><\/div><\/div>
Who<\/span><\/h2><\/div>Veterans enrolled in the VA health care systems across the US<\/span> that tested for COVID-19 (71,175<\/span> patients<\/span>).<\/span> 4,599 patients had vitamin D levels tested within 15-90 days of their COVID-19 tests.<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Things to Keep in Mind<\/span><\/h2><\/div>This is a straightforward chart review and comparison, but it should be noted that these patients were all hospitalized which one can assume means these were the worst cases, and we don\u2019t know about health conditions not reviewed in the study that might increase risk and severity of symptoms or might influence vitamin D status.<\/span><\/p>\n <\/p>\n<\/div><\/div><\/div><\/div><\/div>
Author\u2019s Conclusions<\/span><\/h2><\/div><\/div><\/div>“<\/span><\/h2><\/div><\/div><\/div>Continuous blood 25(OH)D concentrations are independently associated with COVID-19-related hospitalization and mortality in an inverse dose-response relationship in this large racially and ethnically diverse cohort of VA patients. Randomized controlled trials are needed to evaluate the impact of vitamin D supplementation on COVID-19-related outcomes.<\/span><\/span><\/p>\n<\/div><\/div><\/div>“<\/span><\/h2><\/div><\/div><\/div><\/div><\/div>Study Design<\/span><\/h2><\/div>\n- Retrospective Cohort Study<\/span><\/span><\/li>\n<\/ul>\n
\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Reference<\/span><\/h2><\/div>Seal KH, <\/span>Bertenthal<\/span> D, Carey E, Grunfeld C, <\/span>Bikle<\/span> DD, Lu CM. Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality. J Gen Intern Med. 2022 Jan 1:1\u20139. <\/span>doi<\/span>: 10.1007\/s11606-021-07170-0. <\/span>Epub<\/span> ahead of print. PMID: 34981368; PMCID: PMC8723909.<\/span><\/p>\n<\/div><\/div><\/div>
Take Home Message<\/span><\/h2><\/div>Vitamin D deficiency has a significant dose-response relationship with adverse clinical <\/span>outcomes<\/span> of COVID-19 infection, including hospitalization and mortali<\/span>ty.<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Results<\/span><\/h2><\/div><\/div><\/div>\n- \n
\n- 14.5% had vitamin D deficiency (< 20 ng\/dl).<\/span>\u00a0<\/span><\/li>\n<\/ul>\n
\n- African American patients, patients living in areas of high poverty, and those with alcohol and drug use had the highest risk for low vitamin D levels.<\/span>\u00a0<\/span><\/li>\n
- There is a significant inverse relationship between vitamin D concentrations and COVID-19 related hospitalization.<\/span>\u00a0<\/span><\/li>\n
- Patients with lower vitamin D concentrations, increases in vitamin D are associated with larger reductions in probability for hospitalization than among those with higher vitamin D concentrations.<\/span>\u00a0<\/span><\/li>\n
- COVID patients with a vitamin D level of 15 ng\/ml compared to 40 ng\/ml had a 20% greater with of hospitalization.\u00a0<\/span>\u00a0<\/span><\/li>\n
- COVID patients with a vitamin D level of 15 ng\/ml compared to 40 ng\/ml had a 53% increased risk of mortality.\u00a0<\/span>\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/span><\/div><\/div><\/div><\/div><\/div>
Who<\/span><\/h2><\/div>Veterans enrolled in the VA health care systems across the US<\/span> that tested for COVID-19 (71,175<\/span> patients<\/span>).<\/span> 4,599 patients had vitamin D levels tested within 15-90 days of their COVID-19 tests.<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Things to Keep in Mind<\/span><\/h2><\/div>This is a straightforward chart review and comparison, but it should be noted that these patients were all hospitalized which one can assume means these were the worst cases, and we don\u2019t know about health conditions not reviewed in the study that might increase risk and severity of symptoms or might influence vitamin D status.<\/span><\/p>\n <\/p>\n<\/div><\/div><\/div><\/div><\/div>
Author\u2019s Conclusions<\/span><\/h2><\/div><\/div><\/div>“<\/span><\/h2><\/div><\/div><\/div>Continuous blood 25(OH)D concentrations are independently associated with COVID-19-related hospitalization and mortality in an inverse dose-response relationship in this large racially and ethnically diverse cohort of VA patients. Randomized controlled trials are needed to evaluate the impact of vitamin D supplementation on COVID-19-related outcomes.<\/span><\/span><\/p>\n<\/div><\/div><\/div>“<\/span><\/h2><\/div><\/div><\/div><\/div><\/div>Study Design<\/span><\/h2><\/div>\n- Retrospective Cohort Study<\/span><\/span><\/li>\n<\/ul>\n
\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>Reference<\/span><\/h2><\/div>Seal KH, <\/span>Bertenthal<\/span> D, Carey E, Grunfeld C, <\/span>Bikle<\/span> DD, Lu CM. Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality. J Gen Intern Med. 2022 Jan 1:1\u20139. <\/span>doi<\/span>: 10.1007\/s11606-021-07170-0. <\/span>Epub<\/span> ahead of print. PMID: 34981368; PMCID: PMC8723909.<\/span><\/p>\n<\/div><\/div><\/div>
Vitamin D deficiency has a significant dose-response relationship with adverse clinical <\/span>outcomes<\/span> of COVID-19 infection, including hospitalization and mortali<\/span>ty.<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div> Veterans enrolled in the VA health care systems across the US<\/span> that tested for COVID-19 (71,175<\/span> patients<\/span>).<\/span> 4,599 patients had vitamin D levels tested within 15-90 days of their COVID-19 tests.<\/span><\/span>\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div> This is a straightforward chart review and comparison, but it should be noted that these patients were all hospitalized which one can assume means these were the worst cases, and we don\u2019t know about health conditions not reviewed in the study that might increase risk and severity of symptoms or might influence vitamin D status.<\/span><\/p>\n <\/p>\n<\/div><\/div><\/div><\/div><\/div> Continuous blood 25(OH)D concentrations are independently associated with COVID-19-related hospitalization and mortality in an inverse dose-response relationship in this large racially and ethnically diverse cohort of VA patients. Randomized controlled trials are needed to evaluate the impact of vitamin D supplementation on COVID-19-related outcomes.<\/span><\/span><\/p>\n<\/div><\/div><\/div> \u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div> Seal KH, <\/span>Bertenthal<\/span> D, Carey E, Grunfeld C, <\/span>Bikle<\/span> DD, Lu CM. Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality. J Gen Intern Med. 2022 Jan 1:1\u20139. <\/span>doi<\/span>: 10.1007\/s11606-021-07170-0. <\/span>Epub<\/span> ahead of print. PMID: 34981368; PMCID: PMC8723909.<\/span><\/p>\n<\/div><\/div><\/div>Results<\/span><\/h2><\/div><\/div><\/div>
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<\/span><\/div><\/div><\/div><\/div><\/div>Who<\/span><\/h2><\/div>
Things to Keep in Mind<\/span><\/h2><\/div>
Author\u2019s Conclusions<\/span><\/h2><\/div><\/div><\/div>
“<\/span><\/h2><\/div><\/div><\/div>
“<\/span><\/h2><\/div><\/div><\/div><\/div><\/div>
Study Design<\/span><\/h2><\/div>
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Reference<\/span><\/h2><\/div>